अमूर्त

Synthesis and Characterization of Pharmaceutical salt of Prulifloxacin

Raghuram Morampudi , Mohammad Sarwar Alam , Mohan Prasad , Chandra Has Khanduri

The selection of an appropriate salt form for a potential drug candidate is an opportunity to modulate its characteristics to improve bioavailability, stability, manufacturability, and patient compliance. In the present study prulifloxacin was subjected to pharmaceutical acceptable acid fumaricacid. The fumarate salt was characterised by powder X-ray diffraction (PXRD), infrared (IR), differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (1H NMR) and subsequently evaluated aqueous solubility and hygroscopicity (DVS). The prulifloxacin fumarate salt shows better thermal characteristics and excellent solubility.