Hari Krishna*
A New method was established for simultaneous estimation of Atorvastatin calcium and Ramipril by RP-HPLC method. Chromatographic separations were carried using Phenomenex Luna C18 (250 × 4.6 mm, 5 μm) column with a mobile phase composition of methanol in addition to phosphate cradle (0.1% v/v triethylamine pH 4.5 well balanced with 0.1% v/v orthophosphoric harsh) have been delivered at a flow rate of 1 ml/min and the detection was carried out using waters HPLC auto sampler, separation module 2695 HPLC system with PDA detector at wavelength 254 nm. The running time 12 min. The retention time for Atorvastatin and Ramipril were 3.02 and 6.10 minute respectively. The correlation coefficient values in linearity were found to be 0.999 and concentration range 20-70 μg/ml for Atorvastatin and 20-70 µg/ml for Ramipril respectively. For accuracy The total recovery was found to be 99.8% and 99.8% for Atorvastatin and Ramipril. LOD and LOQ for Atorvastatin 2.95 and 9.96. LOD and LOQ for Ramipril 3.34 and 10.05.
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