1 In Vitro and In Vivo Evaluation of Whole and Half Tablet of Metoprolol Sustained Release Tablets

Mingjin Xun2*, Zhong Feng1,2,3, Yajie Hao2,3, Qingyan Cui2,3, Liying Zhai2,3, Hui Li2,3, Guimin Zhang2,3

Objective: To investigate the dissolution in vitro and pharmacokinetics in vivo of the original product of metoprolol succinate sustained release tablets and the self-made product.

Methods: In whole tablets and half tablets, a similarity factor (f2) method was used, where the dissolution profiles in four dissolution mediums and pharmacokinetic characteristics in two Beagle dogs of the whole metoprolol succinate sustained release tablets were compared with that of half tablets.

Results: The dissolution behavior of the whole tablets in vitro was similar to that of half tablets and there was no significant difference in the pharmacokinetic parameters tmax and t1/2/h (P>0.05). The Area Under the Concentration time curve (AUC) of half tablet is about half of whole tablet.

Conclusion: The in vitro dissolution and in vivo pharmacokinetics of the whole metoprolol succinate sustained release tablets and the half tablets are similar.

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